What effects would occur in cell A with the active Phospholipase C compared to a non-functional GPCR?

What effects would occur in cell A with the active Phospholipase C compared to a non-functional GPCR?

• A. Cell A will divide while Cell B remains inactive
• B. Cell A will be inactive while Cell B divides
• C. Both cells will be inactive
• D. Both cells will divide optimally

Answer: (A)

The active Phospholipase C plays a critical role in cellular signaling pathways, particularly those initiated by G protein-coupled receptors (GPCRs). When phospholipase C is active, it catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG). This signaling cascade leads to the release of calcium ions from the endoplasmic reticulum and activates protein kinase C (PKC), ultimately promoting various cellular responses such as cell division. In contrast, if the GPCR is non-functional, it cannot activate phospholipase C or initiate the signaling cascade necessary for cell division. Consequently, without the active signaling pathway that promotes proliferation, cell B will remain inactive. Cell A, on the other hand, is influenced by the active phospholipase C; thus, it will proceed to divide due to the signals derived from the activation of the phospholipase C pathway. This means that while cell A is experiencing cellular division due to the active signaling from phospholipase C, cell B remains inactive because the pathway is not initiated from the dysfunctional GP

The active Phospholipase C plays a critical role in cellular signaling pathways, particularly those initiated by G protein-coupled receptors (GPCRs). When phospholipase C is active, it catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG). This signaling cascade leads to the release of calcium ions from the endoplasmic reticulum and activates protein kinase C (PKC), ultimately promoting various cellular responses such as cell division.

In contrast, if the GPCR is non-functional, it cannot activate phospholipase C or initiate the signaling cascade necessary for cell division. Consequently, without the active signaling pathway that promotes proliferation, cell B will remain inactive. Cell A, on the other hand, is influenced by the active phospholipase C; thus, it will proceed to divide due to the signals derived from the activation of the phospholipase C pathway.

This means that while cell A is experiencing cellular division due to the active signaling from phospholipase C, cell B remains inactive because the pathway is not initiated from the dysfunctional GP